https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26346 Wed 11 Apr 2018 13:23:03 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25795 Wed 11 Apr 2018 12:09:43 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35898 Tue 14 Jan 2020 11:55:50 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33809 -4). We did not find evidence that SNP genotype was influencing the DMR in this cohort. A smaller MHC DMR was also identified at HCG4B, and two non-MHC DMRs at PM20D1 on chr1 and ERICH1 on chr8 were also identified. Conclusions: The findings from this study confirm our previous results of a DMR at HLA-DRB1 and also suggest hypermethylation in an independent MHC locus, RNF39, is associated with MS. Taken together, our results highlight the importance of epigenetic factors at the MHC locus in MS independent of treatment, age and sex. Prospective studies are now required to discern whether methylation at MHC is involved in influencing risk of disease onset or whether the disease itself has altered the methylation profile.]]> Tue 03 Sep 2019 18:30:43 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:18790 Sat 24 Mar 2018 07:51:07 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35542 Mon 26 Aug 2019 15:28:04 AEST ]]>